Part 1: Background, Define the problem (~2 pages)
Select a disease or injury (problem) that needs a tissue engineered treatment strategy (solution). Why is this an important problem to solve? Cite statistics or other data from the literature to support your selection of disease/injury. What are the current treatments available clinically for this disease/injury, and what are their limitations/downsides?
Part 2: Propose a solution (~2 pages)
Design a tissue engineered treatment strategy to repair the diseased/injured tissue. (Note: must have a biomaterial/scaffold component, not just cells or growth factors). What are the components of the treatment/device? Be specific about cell type and source, scaffold/matrix material (natural or synthetic, plant or animal origin, etc.), and any biologic factors present. How is each component of your design crucial to the function of your TE solution?
Part 3: Approach/Methods and Clinical Relevance (~2 pages)
Describe in detail how your treatment strategy is fabricated. Is this methodology scalable (i.e., could your strategy be mass-produced and easily implemented in the clinic)? If not, what are its limitations? What changes to your strategy would need to be made to allow for it to be scalable and easy to use in the clinic?
Part 4: Testing (~2 pages)
What steps would be involved in testing the efficacy of your TE strategy? Which specific in vitro tests do you propose to do? Which specific animal model(s) do you propose to do? Justify your selection of each. At each step of testing, what are the expected outcomes? In other words, how do you expect the host cells (in vitro) and tissue (in vivo) to respond to and interact with your TE strategy? Conversely, how will your biomaterial behave upon implantation? What is the predicted timeline of each of these responses?
Guidelines for report:
- 3-4 members per group. List each name beside the part (1-4) completed. *For groups of 3, the background section should be shared.
- 8-10 pages in length, double-spaced (not including references)
- 1-2 (relevant) figures are encouraged
- Minimum of 10 (journal article) references
- Must cite references throughout the report (in the text), not just list them at the end
Guidelines for presentation:
- 7-8 minute presentation, 2 minutes for questions
- Each group member should present his/her part from the report
- Use as many figures as possible