Select one of the case studies below for your assignment. In your discussion, be sure to integrate your knowledge of advanced pathophysiology across the lifespan with the clinical implications for the advanced practice nurse Case Study Assignment Requirements: Make sure all of the topics in the case study have been addressed. Cite at least three references in your case study paper; this may include peer-reviewed journal articles, textbooks, or evidence-based practice websites to support the content. All reference sources must be within 5 years. Do not use sources such as Wikipedia or UpToDate as a reference. Assignments must have at least four full pages of analytic content, double-spaced (the cover and reference pages do not count in the page count, but must be included with the assignment), and follow APA 7th edition format. Case Study 1: Cellular Adaptation, Injury, and Death Maria is a sedentary, 68-year-old woman who is overweight. She complains that her hands and feet are always cold, and she tires quickly when cleaning the house. At her most recent visit to her doctor, her blood pressure was 184/98 mm Hg. She has edema around her ankles and legs, and her physician is concerned about an echocardiogram that indicates Maria has an enlarged heart. Identify two reasons why Maria will have tissue ischemia. How might this lead to hypoxia? What are the two early and reversible changes that occur to tissue cells when they are hypoxic? What specific type of cellular adaptation has taken place in Maria’s enlarged heart? What made you come to this conclusion?