Genomicmedicine provides opportunities to personalize cancer therapy for an individual patient. Although novel targeted therapies prolong survival, most patients with cancer continue to suffer from burdensome symptoms including pain, depres- sion, neuropathy, nausea and vomiting, and infections, which significantly impair quality of life. Suboptimal management of these symptoms can negatively affect response to cancer treat- ment and overall prognosis. The effect of genetic variation on drug response—otherwise known as pharmacogenomics—is well documented and directly influences an individual patient’s response to antiemetics, opioids, neuromodulators, antidepres- sants, antifungals, and more. The growing body of pharmacoge- nomic data can now guide clinicians to select the safest and most effective supportive medications for an individual patient with cancer from the very first prescription.This review outlines a theoretical patient case and the implications of using pharma- cogenetic test results to personalize supportive care throughout the cancer care continuum.
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