FRONTALIN

Research for literature in chemistry direction:
1. Introduction:
Please explain what is Frontalin
What are physical properties of Frontalin
Why people are interested on this compound
Why we study this compound
Application on this compound
What researches done so far on this compound

2. Majority of the grade is here:
Please do not explain about the procedure of the experiment.
Just write about three different ways to synthesis this compound. The explanation for each way of synthesis goes to separate paragraphs. For each synthesis write scheme, list compounds involve to synthesis and talk about scheme in paragraph form. (talk about what happens in each step of synthesis and what are the chemical reagent uses for each synthesis). Name of the person who created this way of synthesis and when he/ she did this synthesis. Draw the synthesis scheme and explain each step. Electronically copy paste of the step by step synthesis A—B—C is ok; or you can use Draw chem. program for drawing.

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For example:

The stereocontrolled synthesis of all-carbon quaternary centers is a formidable challenge in asymmetric synthesis. Alkylation of an enolate is a fundamental reaction which may be used towards this task. While progress has been made using catalytic asymmetric methods in allylation and arylation, the majority of direct alkylation methods continue to require the use of chiral auxiliaries. Professor James Gleason of McGill University has developed an elegant method of preparing quaternary carbons using a chiral thioglycolate lactam auxiliary.1 The lactam can be alkylated three times; twice using basic enolization and once using reductive enolization, to give alpha quaternary carboxylic acid derivatives (Scheme 1). Each alkylation step occurs in excellent yield and with a high degree of diastereoselectivity. Cleavage of the auxiliary via acidic or reductive conditions furnishes the corresponding carboxylic acid or primary alcohol, respectively.

Scheme 1
Furthermore, from a single chiral auxiliary, access to both antipodes can be achieved simply by altering the order of enolate alkylation. For instance, both enantiomers of 2-ethyl-2-methylpentanoic acid were synthesized in good overall yield and in excellent optical purity (Scheme 2). Importantly, this example illustrates that the third reductive alkylation step proceeds diastereoselectively for both (Z)- or (E)-disubstituted enolates. Gleason and co-workers have demonstrated that synthetically useful groups such as: allyl, functionalized alkyl, and benzyl groups can be introduced at the quaternary center while maintaining good yields and stereocontro.

And so on.
3. One paragraph conclusion:
Is there any more research on it
Which method of synthesis is better
Future about this compound

Compose it in third person POV.
Utilize a Times 12 point font.
Craft your essay in MLA format.
Include an MLA works cited page. This works cited page does NOT count towards your four page total 1100 words.
Use a minimum of six citations. Put the number of the Cited Journal at the end of the paragraph upper case.
Use the following resources
Chemical Abstracts (CA)
Chemical formula Index
Chemical substance Index
General subject Index
Patent Index
Primary Journals:
Journal of American Chemical Society (JACS)
Journal of Organic Chemistry (JOC)
Journal of Biochemistry
Tetrahedron Letters
Tetrahedron
Canadian Journal of Chemistry
Journal of Chemical Education
Journal of Analytical chemistry
Angew. Chemie Int. Ed. (English Edition)
For Physical Data and Introduction
Beilstein (Up to 1959)
Elseviers Encyclopedia of Organic Compounds
Dictionary of Organic Compounds
Handbook of Chemistry and Physics
The Systematic Identification of Organic Compounds
Merck Index